Treatment strategies for clear cell renal cell carcinoma: Past, present and future

Junwei Yang; Kuansong Wang; Zhichun Yang

doi:10.3389/fonc.2023.1133832

Treatment strategies for clear cell renal cell carcinoma: Past, present and future

Front Oncol. 2023 Mar 21:13:1133832. doi: 10.3389/fonc.2023.1133832. eCollection 2023.

Authors

Junwei Yang¹, Kuansong Wang^{2

3

4}, Zhichun Yang¹

Affiliations

¹ Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.
² Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ Department of Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of kidney cancer, which is prone to metastasis, recurrence, and resistance to radiotherapy and chemotherapy. The burden it places on human health due to its refractory nature and rising incidence rate is substantial. Researchers have recently determined the ccRCC risk factors and optimized the clinical therapy based on the disease's underlying molecular mechanisms. In this paper, we review the established clinical therapies and novel potential therapeutic approaches for ccRCC, and we support the importance of investigating novel therapeutic options in the context of combining established therapies as a research hotspot, with the goal of providing diversified therapeutic options that promise to address the issue of drug resistance, with a view to the early realization of precision medicine and individualized treatment.

Keywords: clear cell renal cell carcinoma; cytokine; immune checkpoint inhibitor; immunological substance modification; obesity paradox; renal cancer stem cells; tyrosine kinase inhibitor.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (No. 81673491, 81972490) and the Natural Science Foundation of Hunan Province (No. 2022JJ30792).