Association between IL-6 polymorphisms and Atopic Dermatitis in Chinese Han children

Shuangshuang Huang; Hao Wang; Huiwen Zheng; Wei Li; Jianrong Shi; Chen Shen; Ran Tao

doi:10.3389/fped.2023.1156659

Association between IL-6 polymorphisms and Atopic Dermatitis in Chinese Han children

Front Pediatr. 2023 Mar 21:11:1156659. doi: 10.3389/fped.2023.1156659. eCollection 2023.

Authors

Shuangshuang Huang¹, Hao Wang¹, Huiwen Zheng², Wei Li¹, Jianrong Shi¹, Chen Shen^{3

4}, Ran Tao¹

Affiliations

¹ Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
² Department of Dermatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
³ Department of Data and Information, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
⁴ Sino-Finland Joint AI Laboratory for Child Health of Zhejiang Province, Hangzhou, China.

Abstract

Introduction: Atopic Dermatitis (AD) is a chronic inflammatory skin disease that affects almost 20% of children and 2 -10% of adults worldwide. Previous studies revealed that Interleukin-6 (IL-6) plays an essential role in autoimmune and chronic inflammatory diseases. This study aims to investigate the associations between IL-6 polymorphisms and AD.

Methods: Blood samples were collected from 132 AD patients and 100 controls, and single nucleotide polymorphisms (SNPs) in IL-6 (rs2069840 (C/G), rs2066992 (G/T), rs2069837 (A/G) and rs1800796 (G/C)) were analyzed using Multiplex PCR-Based Next Generation Sequencing (NGS).

Results: Results showed that the A/G genotype of IL-6/rs2069837 was significantly associated with a 1.933-fold increased risk of AD compared to those patients with A/A genotype (OR 1.933; 95%CI 1.086-3.438; p=0.024). The combined A/G-G/G genotype raised AD risk by 1.856 times compared to patients with the A/A genotype in dominant model (OR: 1.856; 95% CI: 1.056-3.261; p=0.030). No association was observed for 3 other SNPs and 4 haplotypes.

Discussion: These findings suggested that the A/G genotype of IL-6/rs2069837 was more susceptible to AD than A/A genotype in Chinese Han children, indicating the risk role of IL-6/rs2069837 in the occurrence of AD.

Keywords: IL-6; atopic dermatitis; inflammatory; polymorphisms; susceptibility.

Associated data

figshare/10.6084/m9.figshare.22225282.v1

Grants and funding

This study was supported by Zhejiang Provincial Natural Science Foundation of China (grant no. LY21H040002) and Zhejiang Province Research Project of Public Welfare Technology Application (grant no. LGF22H110001).