A quarter of a century fundamental and translational research in perioperative hypersensitivity and anaphylaxis at the Antwerp university hospital, a Belgian Centre of Excellence of the World Allergy Organization

Didier G Ebo; Nils Vlaeminck; Marie-Line M van der Poorten; Jessy Elst; Alessandro Toscano; Athina L Van Gasse; Margo M Hagendorens; Sophie Aerts; Ine Adriaensens; Vera Saldien; Vito Sabato

doi:10.1016/j.waojou.2023.100759

A quarter of a century fundamental and translational research in perioperative hypersensitivity and anaphylaxis at the Antwerp university hospital, a Belgian Centre of Excellence of the World Allergy Organization

World Allergy Organ J. 2023 Mar 30;16(3):100759. doi: 10.1016/j.waojou.2023.100759. eCollection 2023 Mar.

Authors

Didier G Ebo^{1

2}, Nils Vlaeminck^{1

3}, Marie-Line M van der Poorten^{1

4}, Jessy Elst¹, Alessandro Toscano^{1

5}, Athina L Van Gasse^{1

4}, Margo M Hagendorens^{1

4}, Sophie Aerts³, Ine Adriaensens³, Vera Saldien³, Vito Sabato^{1

2}

Affiliations

¹ Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital and the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.
² Department of Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium.
³ Faculty of Medicine and Health Science, Department of Anaesthesiology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
⁴ Faculty of Medicine and Health Science, Department of Paediatrics, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium.
⁵ Post-graduate School of Allergology and Clinical Immunology, University of Milan, Milan, Italy.

Abstract

Perioperative hypersensitivity constitutes an important health issue, with potential dramatic consequences of diagnostic mistakes. However, safe and correct diagnosis is not always straightforward, mainly because of the application of incorrect nomenclature, absence of easy accessible in-vitro/ex-vivo tests and uncertainties associated with the non-irritating skin test concentrations. In this editorial we summarize the time line, seminal findings, and major realizations of 25 years of research on the mechanisms, diagnosis, and management of perioperative hypersensitivity.

Keywords: Basophils; MRGPRX2; Mast cell; Perioperative hypersensitivity; sIgE.

Publication types

Editorial