Special Population: Pediatric Nonalcoholic Fatty Liver Disease

Eric Dybbro; Miriam B Vos; Rohit Kohli

doi:10.1016/j.cld.2023.01.012

Special Population: Pediatric Nonalcoholic Fatty Liver Disease

Clin Liver Dis. 2023 May;27(2):471-482. doi: 10.1016/j.cld.2023.01.012. Epub 2023 Feb 26.

Authors

Eric Dybbro¹, Miriam B Vos², Rohit Kohli³

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, USA.
² Division of Gastroenterology, Hepatology, and Nutrition, Emory School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
³ Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA, USA. Electronic address: rokohli@chla.usc.edu.

PMID: 37024219
DOI: 10.1016/j.cld.2023.01.012

Abstract

Pediatric nonalcoholic fatty liver disease represents the most common liver disease in children and has been shown to carry significant morbidity. Widespread heterogeneity of disease, as well as the limitation of indirect screening modalities, has made true prevalence of disease difficult to estimate as well as hindered ability to identify optimal prognostic factors in the pediatric population. Current therapeutic options are limited in pediatric patients with current mainstay of therapy, lifestyle modifications, has proven to have a limited efficacy in current clinical application. Current research remains needed in improved screening modalities, prognosticating techniques, and therapeutic options in the pediatric population.

Keywords: Children; Lifestyle modifications; Nonalcoholic steatohepatitis; Obesity.

Publication types

Review

MeSH terms

Child
Humans
Life Style
Non-alcoholic Fatty Liver Disease* / diagnosis
Non-alcoholic Fatty Liver Disease* / epidemiology
Non-alcoholic Fatty Liver Disease* / therapy