The Role Bariatric Surgery and Endobariatric Therapies in Nonalcoholic Steatohepatitis

Aaron Yeoh; Robert Wong; Ashwani K Singal

doi:10.1016/j.cld.2023.01.009

The Role Bariatric Surgery and Endobariatric Therapies in Nonalcoholic Steatohepatitis

Clin Liver Dis. 2023 May;27(2):413-427. doi: 10.1016/j.cld.2023.01.009. Epub 2023 Feb 26.

Authors

Aaron Yeoh¹, Robert Wong², Ashwani K Singal³

Affiliations

¹ Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA, USA.
² Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA, USA; Gastroenterology Section, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA.
³ University of South Dakota Sanford School of Medicine; Avera Medical Group Liver Disease and Transplant Institute, Avera McKennan University Hospital, Clinical Research Affairs Avera Transplant Institute, 1315 South Cliff Avenue, Sioux Falls, SD 57105, USA; VA Medical Center, Sioux Falls, SD, USA. Electronic address: ashwanisingal.com@gmail.com.

PMID: 37024216
DOI: 10.1016/j.cld.2023.01.009

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Disease spectrum varies from steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Currently, there are no approved medical therapies, and weight loss through lifestyle modifications remains a mainstay of therapy. Bariatric surgery is the most effective therapy for weight loss and has been shown to improve liver histology. Recently, endoscopic bariatric metabolic therapies have also emerged as effective treatments for patients with obesity and NAFLD. This review summarizes the role of bariatric surgery and endoscopic therapies in the management of patients with NAFLD.

Keywords: Bariatric endoscopy; Bariatric surgery; Endoscopic bariatric and metabolic therapies; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bariatric Surgery* / adverse effects
Humans
Liver / pathology
Liver Cirrhosis / complications
Liver Neoplasms* / pathology
Non-alcoholic Fatty Liver Disease* / etiology
Non-alcoholic Fatty Liver Disease* / surgery
Weight Loss