Therapeutic restoration of female reproductive and endocrine dysfunction using stem cells

Xiaobo Liu; Jiajia Li; Wenjun Wang; Xue Ren; Ji-Fan Hu

doi:10.1016/j.lfs.2023.121658

Therapeutic restoration of female reproductive and endocrine dysfunction using stem cells

Life Sci. 2023 Jun 1:322:121658. doi: 10.1016/j.lfs.2023.121658. Epub 2023 Apr 4.

Authors

Xiaobo Liu¹, Jiajia Li², Wenjun Wang³, Xue Ren⁴, Ji-Fan Hu⁵

Affiliations

¹ The Laboratory of Cancer Precision Medicine, the First Hospital of Jilin University, Changchun, Jilin 130061, China.
² The Laboratory of Cancer Precision Medicine, the First Hospital of Jilin University, Changchun, Jilin 130061, China; Department of Gynecologic Oncology, Gynecology and Obstetrics Centre, the First Hospital of Jilin University, Changchun, Jilin 130012, China.
³ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Cancer Center, First Hospital of Jilin University, Changchun, Jilin 130061, China; Stanford University Medical School, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.
⁴ Department of Gynecologic Oncology, Gynecology and Obstetrics Centre, the First Hospital of Jilin University, Changchun, Jilin 130012, China.
⁵ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Cancer Center, First Hospital of Jilin University, Changchun, Jilin 130061, China; Stanford University Medical School, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address: jifan@stanford.edu.

PMID: 37023951
DOI: 10.1016/j.lfs.2023.121658

Abstract

Millions of women worldwide suffer from infertility associated with gynecologic disorders such as premature ovarian insufficiency, polycystic ovary syndrome, Asherman syndrome, endometriosis, preeclampsia, and fallopian tube obstruction. These disorders can lead to infertility and thereby affect the quality of life of the infertile couple because of their psychological impact and significant costs. In recent years, stem cell therapy has emerged as a therapeutic approach to repair or replace damaged tissues or organs. This review describes the recent development as well as the underlying mechanisms of stem cell therapy for a variety of female reproductive diseases, offering us new therapeutic options for the treatment of female reproductive and endocrine dysfunction.

Keywords: Cell therapy; Infertility; Infertility-causing diseases; Paracrine factors; Stem cell.

Publication types

Review

MeSH terms

Female
Humans
Infertility*
Infertility, Female* / etiology
Infertility, Female* / therapy
Polycystic Ovary Syndrome* / complications
Polycystic Ovary Syndrome* / therapy
Pregnancy
Quality of Life
Reproduction
Stem Cells