Celastrol activates mitochondrial autophagy through Nur77-TRAF2-p62/SQSTM1 pathway in the treatment of experimental colitis

Minerva Pediatr (Torino). 2023 Oct;75(5):760-762. doi: 10.23736/S2724-5276.23.07258-0. Epub 2023 Apr 6.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autophagy* / drug effects
  • Colitis* / drug therapy
  • Colitis* / genetics
  • Colitis* / metabolism
  • Humans
  • Mitochondria* / drug effects
  • Mitochondria* / metabolism
  • Sequestosome-1 Protein / metabolism
  • TNF Receptor-Associated Factor 2 / metabolism

Substances

  • celastrol
  • Nr4a1 protein, mouse
  • Sequestosome-1 Protein
  • Sqstm1 protein, mouse
  • TNF Receptor-Associated Factor 2
  • TRAF2 protein, mouse