Recent progress toward understanding the role of ZIP14 in regulating systemic manganese homeostasis

Shannon McCabe; Kirsten Limesand; Ningning Zhao

doi:10.1016/j.csbj.2023.03.039

Recent progress toward understanding the role of ZIP14 in regulating systemic manganese homeostasis

Comput Struct Biotechnol J. 2023 Mar 23:21:2332-2338. doi: 10.1016/j.csbj.2023.03.039. eCollection 2023.

Authors

Shannon McCabe¹, Kirsten Limesand¹, Ningning Zhao¹

Affiliation

¹ School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA.

Abstract

ZIP14 is a metal transporter essential for the regulation of body manganese homeostasis. The physiological functions of ZIP14 have been uncovered mainly through two lines of in vivo studies that examined the phenotypes of ZIP14 loss, including studies of humans with ZIP14 mutations and animals with ZIP14 deficiency. This mini review aims at presenting an updated view of the important advances made towards understanding the genetic and pathological mechanisms of brain manganese overload caused by ZIP14 deficiency.

Keywords: Manganese; Nutrition; SLC39A14; ZIP14.

Publication types

Review

Grants and funding

R01 DK123113/DK/NIDDK NIH HHS/United States