Research progress on exosomes in podocyte injury associated with diabetic kidney disease

Jiao Li; Shanshan Zheng; Chaoqun Ma; Xuexun Chen; Xuan Li; Shengjie Li; Ping Wang; Ping Chen; Zunsong Wang; Wenbin Li; Yipeng Liu

doi:10.3389/fendo.2023.1129884

Research progress on exosomes in podocyte injury associated with diabetic kidney disease

Front Endocrinol (Lausanne). 2023 Mar 20:14:1129884. doi: 10.3389/fendo.2023.1129884. eCollection 2023.

Authors

Jiao Li¹, Shanshan Zheng¹, Chaoqun Ma², Xuexun Chen³, Xuan Li³, Shengjie Li¹, Ping Wang^{1

4

5}, Ping Chen^{1

4

5}, Zunsong Wang^{1

4

5}, Wenbin Li^{1

4

5}, Yipeng Liu^{1

4

5}

Affiliations

¹ Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
² Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
³ Department of Nephrology, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, China.
⁴ Department of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
⁵ Nephrology Research Institute of Shandong Province, Jinan, China.

Abstract

Diabetic kidney disease (DKD), a common cause of end-stage renal disease, is a serious complication that develops with the progression of chronic diabetes. Its main clinical manifestations are persistent proteinuria and/or a progressive decline in the estimated glomerular filtration rate. Podocytes, terminally differentiated glomerular visceral epithelial cells, constitute the glomerular filtration barrier together with the basement membrane and endothelial cells, and the structural and functional barrier integrity is closely related to proteinuria. In recent years, an increasing number of studies have confirmed that podocyte injury is the central target of the occurrence and development of DKD, and research on exosomes in podocyte injury associated with DKD has also made great progress. The aim of this review is to comprehensively describe the potential diagnostic value of exosomes in podocyte injury associated with DKD, analyze the mechanism by which exosomes realize the communication between podocytes and other types of cells and discuss the possibility of exosomes as targeted therapy drug carriers to provide new targets for and insights into delaying the progression of and treating DKD.

Keywords: biomarkers; communication; diabetic kidney disease; exosomes; microRNA; podocyte injury.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus*
Diabetic Nephropathies*
Endothelial Cells
Exosomes*
Humans
Podocytes*
Proteinuria

Grants and funding

This study was supported by grants from the Young Taishan Scholars Program (tsqn201812143), the Academic Promotion Programme of Shandong First Medical University (2019RC013), the Third Project of Jinan City Science and Technology Development Plan (201503002), and the National Natural Science Foundation of China (81500555 and 82170742).