Apelin-13, a regulator of autophagy, apoptosis and inflammation in multifaceted bone protection

Ge Gong; Wenhui Wan; Xinhui Liu; Jian Yin

doi:10.1016/j.intimp.2023.109991

Apelin-13, a regulator of autophagy, apoptosis and inflammation in multifaceted bone protection

Int Immunopharmacol. 2023 Apr:117:109991. doi: 10.1016/j.intimp.2023.109991. Epub 2023 Mar 9.

Authors

Ge Gong¹, Wenhui Wan¹, Xinhui Liu², Jian Yin³

Affiliations

¹ Department of Geriatrics, Jinling Hospital, Medical School of Nanjing University, Nanjing 211002, China.
² Department of Orthopedics, the Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China. Electronic address: liuxinhuijnyy@163.com.
³ Department of Orthopedics, the Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China. Electronic address: yinjiandoc@163.com.

PMID: 37012875
DOI: 10.1016/j.intimp.2023.109991

Abstract

Apelin/APJ is widely distributed in various tissues in the body and participates in the regulation of physiological and pathological mechanisms such as autophagy, apoptosis, inflammation, and oxidative stress. Apelin-13 is an adipokine family member with multiple biological roles and has been shown to be involved in the development and progression of bone diseases. In the process of osteoporosis and fracture healing, Apelin-13 plays an osteoprotective role by regulating the autophagy and apoptosis of BMSCs, and promotes the osteogenic differentiation of BMSCs. In addition, Apelin-13 also attenuates the progression of arthritis by regulating the inflammatory response of macrophages. In conclusion, Apelin-13 has an important connection with bone protection, which provides a new strategy for the clinical treatment of bone-related diseases.

Keywords: Apelin-13; BMSCs; Bone protection; Osteoprotective effect; PANoptosis.

Publication types

Review

MeSH terms

Apelin Receptors
Apoptosis
Autophagy
Humans
Inflammation*
Osteogenesis*

Substances

apelin-13 peptide
Apelin Receptors