Botryoid-type of embryonal rhabdomyosarcoma of the proximal and mid ureter in an adult woman

Victor Sandoval; Nicole Friesen; Melissa Huynh; Jose A Gomez-Lemus; Nicholas Power

doi:10.1016/j.eucr.2023.102388

Botryoid-type of embryonal rhabdomyosarcoma of the proximal and mid ureter in an adult woman

Urol Case Rep. 2023 Mar 20:48:102388. doi: 10.1016/j.eucr.2023.102388. eCollection 2023 May.

Authors

Victor Sandoval¹, Nicole Friesen², Melissa Huynh¹, Jose A Gomez-Lemus³, Nicholas Power¹

Affiliations

¹ Department of Surgery, Urology Division, University of Western Ontario, London, ON, Canada.
² Western University, London, Ontario, Canada.
³ Department of Pathology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

Abstract

We report a unique case of botryoid-type embryonal RMS of the proximal and mid ureter in a pregnant 29-year-old woman. The ureteral polyp consisted of a malignant small blue round cell tumor with a myxoid background and contained evidence of foci of immature cartilage and aggregates of epithelial cells reminiscent of hair follicle. Immunohistochemical stains for myogenin and desmin confirmed skeletal muscle, or rhabdomyoblastic, differentiation. The compact epithelial cell fragments reminiscent of hair follicle differentiation were positive for p40. Treatment included 6 cycles of adjuvant chemotherapy (vincristine, actinomycin and cyclophosphamide (VAC). No recurrent or metastatic disease was identified post-surgery.

Keywords: Genitourinary; Rhabdomyosarcoma; Soft tissue sarcomas; Ureter.

Publication types

Case Reports