Helicobacter Pylori-Negative MALT Lymphoma: A Series of Two Cases Presenting with Life-Threatening Upper Gastrointestinal Bleeding

Seo Hyun Kim; Youssef Soliman; Vikas N Chitnavis; Maithili V Chitnavis

doi:10.1155/2023/8244696

Helicobacter Pylori-Negative MALT Lymphoma: A Series of Two Cases Presenting with Life-Threatening Upper Gastrointestinal Bleeding

Case Rep Gastrointest Med. 2023 Mar 23:2023:8244696. doi: 10.1155/2023/8244696. eCollection 2023.

Authors

Seo Hyun Kim¹, Youssef Soliman², Vikas N Chitnavis³, Maithili V Chitnavis⁴

Affiliations

¹ Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
² Gastroenterology, City of Hope Phoenix, Goodyear, AZ, USA.
³ Department of Internal Medicine, Division of Gastroenterology, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
⁴ Inflammatory Bowel Disease Section, Atrium Health Gastroenterology, Charlotte, NC, USA.

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is a common cause of gastric lymphoma. Although most cases are associated with an H. pylori infection, approximately 10% are H. pylori-negative. Patients with gastric MALT lymphoma are usually asymptomatic or present with nonspecific symptoms such as abdominal pain, dyspepsia, weight loss, and occult gastrointestinal bleeding. In this report, we describe two patients with H. pylori-negative MALT lymphoma who both presented with acute upper gastrointestinal bleeding that led to hemodynamic instability. After resuscitation, emergent endoscopy was performed. Both patients had the t (11; 18) (q21; q21) translocation, which prompted direct treatment by radiotherapy.

Publication types

Case Reports