An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases

Sally S Ong; S Tammy Hsu; Arathi Ponugoti; Cynthia A Toth; Lejla Vajzovic

doi:10.1177/2474126420983679

An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases

J Vitreoretin Dis. 2021 Feb 10;5(5):431-437. doi: 10.1177/2474126420983679. eCollection 2021 Sep-Oct.

Authors

Sally S Ong^{1

2}, S Tammy Hsu², Arathi Ponugoti², Cynthia A Toth², Lejla Vajzovic²

Affiliations

¹ Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.

Abstract

Purpose: This work aimed to examine the microvasculature of macular fibrosis in Coats disease.

Methods: Three boys (aged 3, 4, and 6 years) with Coats disease (stages 2B to 3A2) and macular fibrotic nodules were imaged using optical coherence tomography angiography (OCTA) on the Spectralis spectral-domain OCT tabletop and investigational portable Spectralis Flex module (version 6.9, Heidelberg Engineering).

Results: In 2 eyes, a neovascular complex was observed in the avascular slab on OCTA. This neovascular complex had vessels connected to diving vessels from the superficial vascular complex that traveled through the deep vascular complex to the avascular complex. In the third eye, no neovascular complex was observed on OCTA at presentation, but on subsequent examinations fluorescein leakage was observed and cross-sectional OCTA further confirmed the presence of angiographic flow in the nodule.

Conclusions: OCTA demonstrates the presence of type 3 neovascularization in fibrotic nodules in Coats disease.

Keywords: Coats disease; fibrosis; macular nodules; microvasculature; neovascularization; optical coherence tomography angiography.

Publication types

Case Reports