TR score: A noninvasive model to predict histological stages in patients with primary biliary cholangitis

Zhixin Tu; Yao Wang; Yan Wang; Jianjie Huang; Yujin Han; Qijia Ji; Xiaoxuan Cao; Xiaoyu Wen; Yang Wang; Qinglong Jin

doi:10.3389/fimmu.2023.1152294

TR score: A noninvasive model to predict histological stages in patients with primary biliary cholangitis

Front Immunol. 2023 Mar 16:14:1152294. doi: 10.3389/fimmu.2023.1152294. eCollection 2023.

Authors

Zhixin Tu¹, Yao Wang², Yan Wang¹, Jianjie Huang¹, Yujin Han¹, Qijia Ji¹, Xiaoxuan Cao¹, Xiaoyu Wen¹, Yang Wang¹, Qinglong Jin¹

Affiliations

¹ Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China.
² Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.

Abstract

Introduction: The aim of this study was to develop a noninvasive prediction model for histological stages in PBC that is simple, easy to implement, and highly accurate.

Methods: A total of 114 patients with PBC were included in this study. Demographic, laboratory data and histological assessments were collected. The independent predictors of histological stages were selected to establish a noninvasive serological model. The scores of 22 noninvasive models were calculated and compared with the established model.

Results: This study included 99 females (86.8%) and 15 males (13.2%). The number of patients in Scheuer's stage 1, 2, 3 and 4 was 33 (29.0%), 34 (29.8%), 16 (14.0%), and 31 (27.2%), respectively. TBA and RDW are independent predictors of PBC histological stages. The above indexes were used to establish a noninvasive model-TR score. When predicting early histological change (S1) or liver fibrosis and cirrhosis (S3-S4), the AUROC of TR score were 0.887 (95% CI, 0.809-0.965) and 0.893 (95% CI, 0.816-0.969), higher than all of the other 22 models included in this study. When predicting cirrhosis (S4), its AUROC is still as high as 0.921 (95% CI, 0.837-1.000).

Conclusion: TR score is an easy, cheap and stable noninvasive model, without complex calculation formulas and tools, and shows good accuracy in diagnosing the histological stages of PBC.

Keywords: histological stage; noninvasive model; primary biliary cholangitis; red blood cell distribution width; total bile acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Fibrosis
Humans
Liver Cirrhosis / diagnosis
Liver Cirrhosis, Biliary* / diagnosis
Liver Cirrhosis, Biliary* / pathology
Male
Severity of Illness Index

Grants and funding

This research was funded by the National Natural Science Foundation of China (No.82170535) and the Program of Jilin Financial Department (No. JLSCZD2019-027).