Occupational exposure to diacetyl can lead to bronchiolitis obliterans. In this paper, two patients with severe obstructive ventilation disorder who were exposed to diacetyl at a fragrance and flavours factory were analyzed. The clinical manifestations were cough and shortness of breath. One of them showed Mosaic shadows and uneven perfusion in both lungs on CT, while the other was normal. Field investigation found that 4 of the 8 workers in the factory were found to have obstructive ventilation disorder, and 2 had small airway dysfunction. This paper summarizes the diagnostic process of patients in order to improve the understanding of airway dysfunction caused by occupational exposure to diacetyl and promote the development of relevant standards.
职业接触双乙酰可导致闭塞性细支气管炎，本文分析2例在香精香料厂接触双乙酰的重度阻塞性通气障碍患者，临床表现为咳嗽、气促，其中1例患者CT示马赛克影，两肺灌注不均，另1例CT正常。现场调查发现，8名职工中有4人检出阻塞性通气障碍，2人出现小气道功能障碍。本文总结患者诊断过程，以提高对职业接触双乙酰致气道功能障碍的认知，推动相应标准的制定。.
Keywords: Bronchiolitis, obliterans; Diacetyl; Occupational diseases; Occupational exposure.