Heat Shock Proteins in Non-Small-Cell Lung Cancer-Functional Mechanism

Guanyu Zhou; Yi Pu; Kejia Zhao; Yaohui Chen; Gao Zhang

doi:10.31083/j.fbl2803056

Heat Shock Proteins in Non-Small-Cell Lung Cancer-Functional Mechanism

Front Biosci (Landmark Ed). 2023 Mar 20;28(3):56. doi: 10.31083/j.fbl2803056.

Authors

Guanyu Zhou^{1

2}, Yi Pu^{1

3}, Kejia Zhao^{1

2}, Yaohui Chen^{1

2}, Gao Zhang⁴

Affiliations

¹ Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China.
² Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, 610041 Chengdu, Sichuan, China.
³ Department of Burn and Reconstructive Surgery, Laboratory of Mitochondria and Metabolism, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China.
⁴ Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 999077 Hong Kong, China.

PMID: 37005758
DOI: 10.31083/j.fbl2803056

Abstract

Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancers, which has the highest cancer-related mortality worldwide. Regardless of the therapeutic effects of chemotherapy or targeted therapy, drug resistance will occur after 1 year. Heat shock proteins (HSPs) are a class of molecular chaperones participated in protein stability and multiple intracellular signaling pathways. It has been widely reported that HSPs family is over expressed in non-small cell lung cancer, and these molecules are also associated with protein stability and multiple intracellular signaling pathways. The effect of chemotherapy drugs or targeted drugs on cancer cells is usually to induce apoptosis. It is necessary to explore the interaction between heat shock protein family and apoptosis pathway in NSCLC. Here we provide a brief review of how HSPs affect the apoptotic pathway in NSCLC.

Keywords: Heat shock proteins; apoptotic; non-small cell lung cancer.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Carcinoma, Non-Small-Cell Lung* / drug therapy
Carcinoma, Non-Small-Cell Lung* / genetics
Heat-Shock Proteins / metabolism
Humans
Lung Neoplasms* / drug therapy
Lung Neoplasms* / genetics

Substances

Heat-Shock Proteins