Duration of Fecal Excretion of Clostridium Botulinum and Botulinum Neurotoxin in Patients Recovering from Infant Botulism

Haydee A Dabritz; Jessica R Payne; Jessica M Khouri

doi:10.1016/j.jpeds.2023.113396

Duration of Fecal Excretion of Clostridium Botulinum and Botulinum Neurotoxin in Patients Recovering from Infant Botulism

J Pediatr. 2023 Jul:258:113396. doi: 10.1016/j.jpeds.2023.113396. Epub 2023 Mar 31.

Authors

Haydee A Dabritz¹, Jessica R Payne¹, Jessica M Khouri²

Affiliations

¹ Infant Botulism Treatment and Prevention Program, Infectious Diseases Laboratories Division, Center for Laboratory Sciences, California Department of Public Health, Richmond, CA.
² Infant Botulism Treatment and Prevention Program, Infectious Diseases Laboratories Division, Center for Laboratory Sciences, California Department of Public Health, Richmond, CA. Electronic address: jessica.khouri@cdph.ca.gov.

PMID: 37004956
DOI: 10.1016/j.jpeds.2023.113396

Abstract

This study sought to determine duration of fecal excretion of Clostridium botulinum organisms and neurotoxin after onset of infant botulism in 66 affected infants. Median excretion was longer for type A than type B patients (organisms: 5.9 vs 3.5 weeks, toxin: 4.8 vs 1.6 weeks, respectively). Toxin excretion always ceased before organism excretion. Antibiotic therapy did not affect duration of excretion.

Keywords: Clostridium botulinum; botulinum toxin; detection; fecal excretion; infant botulism.

Publication types

Case Reports

MeSH terms

Botulinum Toxins*
Botulism* / diagnosis
Botulism* / drug therapy
Clostridium
Clostridium botulinum*
Feces
Humans
Infant

Substances

Botulinum Toxins