Stem cells for neonatal brain injury - Lessons from the bench

So Yoon Ahn; Yun Sil Chang; Won Soon Park

doi:10.1016/j.semperi.2023.151726

Stem cells for neonatal brain injury - Lessons from the bench

Semin Perinatol. 2023 Apr;47(3):151726. doi: 10.1016/j.semperi.2023.151726. Epub 2023 Mar 12.

Authors

So Yoon Ahn¹, Yun Sil Chang², Won Soon Park³

Affiliations

¹ Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea; Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, South Korea.
² Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea; Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, South Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAHIST), Samsung Medical Center, Seoul 06351, South Korea.
³ Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea; Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, South Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAHIST), Samsung Medical Center, Seoul 06351, South Korea. Electronic address: wonspark@skku.edu.

PMID: 37003920
DOI: 10.1016/j.semperi.2023.151726

Abstract

Neonatal brain injury resulting from various intractable disorders including intraventricular hemorrhage and hypoxic ischemic encephalopathy still remains a major cause of mortality and morbidities with few effective treatments. Recent preclinical research results showing the pleiotropic neuroprotective effects of stem cell therapy, specifically mesenchymal stem cells (MSCs), suggest that MSCs transplantation might be a promising new therapeutic modality for neuroprotection against the currently intractable and devastating neonatal brain injury with complex multifactorial etiology. This review summarizes recent advances in preclinical stem cell research for treating neonatal brain injury with a focus on the important issues including the mechanism of neuroprotection, and determining the ideal cell source, route, timing and dose of MSCs transplantation.

Keywords: Cerebral intraventricular hemorrhage; Hypoxia-ischemia, Brain; Infant; Mesenchymal stem cells; Neuroprotection; Newborn.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain Injuries* / therapy
Cerebral Hemorrhage / therapy
Humans
Hypoxia-Ischemia, Brain* / therapy
Infant, Newborn
Mesenchymal Stem Cell Transplantation* / methods
Mesenchymal Stem Cells*