The Impact of Surgical Indication on Posttonsillectomy Hemorrhage: A Systematic Review and Meta-Analysis

Otolaryngol Head Neck Surg. 2023 Oct;169(4):780-791. doi: 10.1002/ohn.339. Epub 2023 Apr 1.

Abstract

Objective: To investigate the impact of the surgical indication on posttonsillectomy bleed rates.

Data sources: PubMed, Scopus, CINAHL.

Review methods: A systematic review was performed searching for articles published from the date of inception to July 6, 2022. English language articles describing posttonsillectomy hemorrhage rates in pediatric patients (age ≤ 18) stratified by indication were selected for inclusion. A meta-analysis of proportions with comparison (Δ) of weighted proportions was conducted. All studies were assessed for risk of bias.

Results: A total of 72 articles with 173,970 patients were selected for inclusion. The most common indications were chronic/recurrent tonsillitis (CT/RT), obstructive sleep apnea/sleep-disordered breathing (OSA/SDB), and adenotonsillar hypertrophy (ATH). Posttonsillectomy hemorrhage rates for CT/RT, OSA/SDB, and ATH were 3.57%, 3.69%, and 2.72%, respectively. Patients operated on for a combination of CT/RT and OSA/SDB had a bleed rate of 5.99% which was significantly higher than those operated on for CT/RT alone (Δ2.42%, p = .0006), OSA/SDB alone (Δ2.30%, p = .0016), and ATH alone (Δ3.27%, p < .0001). Additionally, those operated on for a combination of ATH and CT/RT had a hemorrhage rate of 6.93%, significantly higher than those operated on for CT/RT alone (Δ3.36%, p = .0003), OSA/SDB alone (Δ3.01%, p = .0014), and ATH alone (Δ3.98%, p < .0001).

Conclusion: Patients operated on for multiple indications had significantly higher rates of posttonsillectomy hemorrhage than those operated on for a single surgical indication. Better documentation of patients with multiple indications would help further characterize the magnitude of the compounding effect described here.

Keywords: hemorrhage; posttonsillectomy bleed; posttonsillectomy hemorrhage; tonsillectomy.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • Adenoidectomy / adverse effects
  • Child
  • Hemorrhage
  • Humans
  • Hypertrophy / surgery
  • Palatine Tonsil
  • Sleep Apnea, Obstructive* / surgery
  • Tonsillectomy* / adverse effects
  • Tonsillitis* / surgery