3D nanofiber sponge with dimethyloxaloglycine-loaded Prussian blue analogue microspheres to promote wound healing

Jiatian Chen; Zihang Huang; Xiaotong Wu; Dan Xia; Ziyu Chen; Donghui Wang; Chunyong Liang; Jinhua Li

doi:10.1088/1748-605X/acc99b

3D nanofiber sponge with dimethyloxaloglycine-loaded Prussian blue analogue microspheres to promote wound healing

Biomed Mater. 2023 Apr 13;18(3). doi: 10.1088/1748-605X/acc99b.

Authors

Jiatian Chen^{1

2}, Zihang Huang¹, Xiaotong Wu¹, Dan Xia¹, Ziyu Chen¹, Donghui Wang³, Chunyong Liang^{1

3}, Jinhua Li²

Affiliations

¹ Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, People's Republic of China.
² School of Medical Technology, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
³ Center for Health Science and Engineering, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, People's Republic of China.

PMID: 37001530
DOI: 10.1088/1748-605X/acc99b

Abstract

The fabrication of functional wound dressing for effective hemostasis, anti-inflammation as well as angiogenesis is of vital importance. In this paper, a three-dimensional (3D) nanofiber sponge with dimethyloxaloglycine (DMOG) loaded mesoporous spheres of derivatives of Prussian blue analogues (PBAs) was prepared (3D-PBA_FeCo-DMOG). The nanostructure, composition, and mechanical properties of 3D-PBA_FeCo-DMOG were characterized, showing regular nanostructure and good mechanical property. The behavior ofin vitrodrug release showed the DMOG could achieve long-term and stable release by encapsulating in PBA_FeComicrospheres and nanofibers.In vitrocoagulation experiments showed that 3D-PBA_FeCo-DMOG had effective hemostasis and clotting capacities. In addition, the antioxidant capacity and cell compatibility of 3D-PBA_FeCo-DMOG were confirmed. These results indicate that 3D-PBA_FeCo-DMOG nanofiber sponge, as a controlled drug release system, may provide a new strategy for promoting angiogenesis and wound healing for clinical applications.

Keywords: 3D nanofiber sponge; Prussian blue analogues; dimethyloxaloglycine; wound healing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bandages
Microspheres
Nanofibers* / chemistry
Wound Healing

Substances

ferric ferrocyanide