Selective Detection of Choline in Pseudophysiological Medium with a Fluorescent Cage Receptor

Nicolas Fantozzi; Rémi Pétuya; Alberto Insuasty; Germain Salvato Vallverdu; Emilie Genin; Didier Bégué; Alexandre Martinez; Sandra Pinet; Isabelle Gosse

doi:10.1021/acs.orglett.3c00606

Selective Detection of Choline in Pseudophysiological Medium with a Fluorescent Cage Receptor

Org Lett. 2023 Apr 14;25(14):2444-2449. doi: 10.1021/acs.orglett.3c00606. Epub 2023 Mar 31.

Authors

Nicolas Fantozzi¹, Rémi Pétuya², Alberto Insuasty³, Germain Salvato Vallverdu², Emilie Genin¹, Didier Bégué², Alexandre Martinez³, Sandra Pinet¹, Isabelle Gosse¹

Affiliations

¹ Université Bordeaux, CNRS, Bordeaux INP, Institut des Sciences Moléculaires, UMR 5255, F-33405 Talence, France.
² Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, Institut des Sciences Analytiques et de Physicochimie pour l'Environnement, UMR 5254, 64053 Pau, France.
³ Aix Marseille Univ., CNRS, Centrale Marseille, iSm2, UMR 7313, 13397 Marseille, France.

PMID: 37000042
DOI: 10.1021/acs.orglett.3c00606

Abstract

A fluorescent cage receptor for the detection of choline in pseudophysiological medium is described. Not only does this capsule complex choline with an association constant greater than 9.9 × 10⁴ M^-1 in buffered medium but it is also selective toward acetylcholine.