Complex Oligomers and their Bioactivity of Annonaceae Family

Comb Chem High Throughput Screen. 2023;26(14):2424-2436. doi: 10.2174/1386207326666230329090413.

Abstract

Background: A series of novel oligomers with various types and complex skeletons are isolated from Annonaceae plants, which displayed anti-inflammatory, antimalarial, antibacterial and other biological activities. Thus, their structures and functions have received more and more attention.

Aim and objective: The purpose of this review is to provide a systematic reference for chemical structures and biological activities of oligomers and some clues for finding more analogues from Annonaceae.

Methods: Publications relevant to Annonaceae were retrieved from the Web of Science and SciFinder and surveyed for a literature review.

Results: This article summarized the chemical structures, the base source plants and the biofunctions of oligomers from Annonaceae.

Conclusion: The oligomers from Annonaceae have the characteristics of various connection modes and rich functional groups, which provides more possibilities for the discovery of lead compounds with new or higher biological activities.

Keywords: Annonaceae; alkaloid; bioactivity; flavonoid; oligomers; terpenoid.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annonaceae* / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antimalarials* / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antimalarials