Ct, IL-18 polymorphism, and laboratory biomarkers for predicting chemosensory dysfunctions and mortality in COVID-19

Shukur Wasman Smail; Esmaeil Babaei; Kawa Amin

doi:10.2144/fsoa-2022-0082

Ct, IL-18 polymorphism, and laboratory biomarkers for predicting chemosensory dysfunctions and mortality in COVID-19

Future Sci OA. 2023 Mar 9;9(2):FSO838. doi: 10.2144/fsoa-2022-0082. eCollection 2023 Feb.

Authors

Shukur Wasman Smail¹, Esmaeil Babaei^{2

3}, Kawa Amin⁴

Affiliations

¹ Department of Biology, College of Science, Salahaddin University-Erbil, Iraq.
² Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.
⁴ College of Medicine, University of Sulaimani, Sulaymaniyah, Iraq.

Abstract

Aim: Patients with COVID-19 often experience chemosensory dysfunction. This research intends to uncover the association of RT-PCR Ct value with chemosensory dysfunctions and SpO₂. This study also aims to investigate Ct, SpO₂, CRP, D-dimer, and -607 IL-18 T/G polymorphism in order to find out predictors of chemosensory dysfunctions and mortality.

Materials & methods: This study included 120 COVID-19 patients, of which 54 were mild, 40 were severe and 26 were critical. CRP, D-dimer, RT-PCR, and IL-18 polymorphism were evaluated. Results & conclusion: Low Ct was associated with SpO₂ dropping and chemosensory dysfunctions. IL-18 T/G polymorphism did not show an association with COVID-19 mortality; conversely, age, BMI, D-dimer and Ct values did.

Keywords: COVID-19; chemosensory dysfunctions; cyclic threshold; polymorphism and predictors.

Plain language summary

This research intends to uncover the association of RT-PCR Ct value with GD, OD, and SpO₂. It also aims to investigate Ct, SpO₂, CRP, D-dimer and -607 IL-18 T/G polymorphism as predictors of chemosensory dysfunctions and mortality. This study included 120 COVID-19 patients, of which 54 were mild, 40 were severe and 26 were critical. Low Ct was associated with SpO₂ dropping, GD, and OD. IL-18 T/G polymorphism did not show an association with COVID-19 mortality, conversely, age, BMI, D-dimer and Ct values did.