Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution

Tao Zhang; Kangyao Chen; Xing Wu; Xiufeng Xiao

doi:10.1080/15685551.2023.2194175

Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution

Des Monomers Polym. 2023 Mar 26;26(1):77-89. doi: 10.1080/15685551.2023.2194175. eCollection 2023.

Authors

Tao Zhang^{1

2}, Kangyao Chen^{1

2

3}, Xing Wu^{1

2

3}, Xiufeng Xiao⁴

Affiliations

¹ Department of Orthopedics Institute, Fuzhou Second Hospital of Xiamen University, Fuzhou China.
² Department of Orthopedics Institute,The Third Clinical Medical College, Fujian Medical University, Fuzhou.
³ Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, China.
⁴ Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Material Science, Fujian Normal University, Fuzhou, China.

Abstract

Porous nanofibrous poly (L-lactic acid) (PLLA) scaffolds were fabricated in combination with a thermally induced phase separation technique using a dioxane/polyethylene glycol (PEG) system. The effect of factors such as molecular weight of PEG, aging treatment, aging or gelation temperature, and the ratio of PEG to dioxane were investigated. The results revealed that all scaffolds had high porosity, and had a significant impact on the formation of nanofibrous structures. The decrease in the molecular weight and aging or gelation temperature leads to a thinner and more uniform fibrous structure.

Keywords: Poly (L-lactic acid); nanofibrous; phase separation; polyethylene glycol.

Grants and funding

The work was supported by the Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma [2020Y2014].