Cerebral oxygenation immediately after birth and long-term outcome in preterm neonates-a retrospective analysis

Abstract

Background: Prematurity is associated with increased risk for morbidity and mortality. Aim of this study was to evaluate whether cerebral oxygenation during fetal-to-neonatal transition period was associated with long-term outcome in very preterm neonates.

Methods: Preterm neonates ≤ 32 weeks of gestation and/or ≤ 1500 g with measurements of cerebral regional oxygen saturation (crSO₂) and cerebral fractional tissue oxygen extraction (cFTOE) within the first 15 min after birth were analysed retrospectively. Arterial oxygen saturation (SpO₂) and heart rate (HR) were measured with pulse oximetry. Long-term outcome was assessed at two years using "Bayley Scales of Infant Development" (BSID-II/III). Included preterm neonates were stratified into two groups: adverse outcome group (BSID-III ≤ 70 or testing not possible due to severe cognitive impairment or mortality) or favorable outcome group (BSID-III > 70). As the association between gestational age and long-term outcome is well known, correction for gestational age might disguise the potential association between crSO₂ and neurodevelopmental impairment. Therefore, due to an explorative approach the two groups were compared without correction for gestational age.

Results: Forty-two preterm neonates were included: adverse outcome group n = 13; favorable outcome group n = 29. Median(IQR) gestational age and birth weight were 24.8 weeks (24.2-29.8) and 760 g (670-1054) in adverse outcome group and 30.6 weeks (28.1-32.0) (p = 0.009*) and 1250 g (972-1390) (p = 0.001*) in the favorable outcome group, respectively. crSO₂ was lower (significant in 10 out of 14 min) and cFTOE higher in adverse outcome group. There were no difference in SpO₂, HR and fraction of inspired oxygen (FiO₂), except for FiO₂ in minute 11, with higher FiO₂ in the adverse outcome group.

Conclusion: Preterm neonates with adverse outcome had beside lower gestational age also a lower crSO₂ during immediate fetal-to-neonatal transition when compared to preterm neonates with age appropriate outcome. Lower gestational age in the adverse outcome group would suggest beside lower crSO₂ also lower SpO₂ and HR in this group, which were however similar in both groups.

Keywords: BSID III 9; Cerebral regional oxygen saturation (crSO2) 3; Fetal-to-neonatal transition 4; Long-term outcome 8; Morbidity 5; Mortality 6; Near-infrared spectroscopy 2; Neurodevelopmental disability 10; Preterm infant 1; Short-term outcome 7.