Immunogenicity, efficacy, and safety of human papillomavirus vaccine: Data from China

Front Immunol. 2023 Mar 13:14:1112750. doi: 10.3389/fimmu.2023.1112750. eCollection 2023.

Abstract

The incidence rate and mortality rate of cervical cancer have steadily increased in young women in China. Therefore, it is critical to improve HPV vaccination rates, particularly for the younger population. There are currently five types of prophylactic vaccines in China: bivalent HPV vaccine (AS04-HPV-16/18), quadrivalent HPV vaccine, 9-valent HPV vaccine, homemade Escherichia coli-produced HPV bivalent vaccine, and Pichia pastoris produced HPV bivalent vaccine. All these five HPV vaccines have completed relevant clinical trials in China, and have been proven to be generally well-tolerated and immunogenic, efficacious against persistent HPV-related infections and genital precancerous lesions (data for 9-valent HPV vaccine is absent), and have demonstrated acceptable safety profiles, as previously shown in global studies. Given that the HPV vaccination rate in China is still very low, additional HPV vaccine coverage is needed to reduce the incidence and mortality rates of cervical cancer.

Keywords: China; efficacy; human papillomavirus vaccine; immunogenicity; safety.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • China / epidemiology
  • Female
  • Human Papillomavirus Viruses
  • Human papillomavirus 16
  • Human papillomavirus 18
  • Humans
  • Papillomavirus Infections* / epidemiology
  • Papillomavirus Infections* / prevention & control
  • Papillomavirus Vaccines*
  • Uterine Cervical Neoplasms* / epidemiology
  • Uterine Cervical Neoplasms* / prevention & control
  • Vaccines, Combined

Substances

  • Papillomavirus Vaccines
  • Vaccines, Combined

Grants and funding

This work was supported by The National Key Research and Development Program of China (2021YFC2701200) (2021YFC2701202) and Peking University People’s Hospital Scientific Research Development Funds (RDL2022-34).