Systematic review of acupuncture to improve ovarian function in women with poor ovarian response

Rong-Rong Wang; Meng-Hua Su; Li-Ying Liu; Yuan-Yuan Lai; Xiao-Li Guo; Di Gan; Xiao-Yan Zheng; Han Yang; Si-Yi Yu; Fan-Rong Liang; Wei Wei; Ying Zhong; Jie Yang

doi:10.3389/fendo.2023.1028853

Systematic review of acupuncture to improve ovarian function in women with poor ovarian response

Front Endocrinol (Lausanne). 2023 Mar 13:14:1028853. doi: 10.3389/fendo.2023.1028853. eCollection 2023.

Authors

Rong-Rong Wang¹, Meng-Hua Su¹, Li-Ying Liu¹, Yuan-Yuan Lai¹, Xiao-Li Guo², Di Gan², Xiao-Yan Zheng¹, Han Yang¹, Si-Yi Yu¹, Fan-Rong Liang¹, Wei Wei², Ying Zhong², Jie Yang^{1

2

3}

Affiliations

¹ Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
² Traditional Chinese Medicine Department, Chengdu Xi'nan Gynecology Hospital, Chengdu, Sichuan, China.
³ Clinical Research Center for Acupuncture and Moxibustion in Sichuan Province, Chengdu, Sichuan, China.

Abstract

Objective: To determine the effect of acupuncture in treating poor ovarian response (POR).

Methods: We searched MEDLINE (via PubMed), EMBASE, Allied and Complementary Medicine Database, CNKI, CBM, VIP database, Wanfang Database, and relevant registration databases from inception to January 30, 2023. In this review, both Chinese and English peer-reviewed literature were included. Only randomized controlled trials (RCTs) using acupuncture as an intervention for POR patients undergoing in vitro fertilization were considered.

Results: Seven clinical randomized controlled trials (RCTs) were eventually included for comparison (516 women). The quality of included studies was generally low or very low. For the meta-analysis, seven studies showed that compared with controlled ovarian hyperstimulation (COH) therapy, acupuncture combined with COH therapy could significantly increase the implantation rate (RR=2.13, 95%CI [1.08, 4.21], p=0.03), the number of oocytes retrieved (MD=1.02, 95%CI [0.72, 1.32], p<0.00001), the thickness of endometrium (MD=0.54, 95%CI [0.13, 0.96], p=0.01), and the antral follicle count (MD=1.52, 95%CI [1.08, 1.95], p<0.00001), reduce follicle-stimulating hormone (FSH) levels (MD=-1.52, 95%CI [-2.41, -0.62], p=0.0009) and improve estradiol (E₂) levels (MD=1667.80, 95%CI [1578.29, 1757.31], p<0.00001). Besides, there were significant differences in the duration of Gn (MD=0.47, 95%CI [-0.00, 0.94], p=0.05) between the two groups. However, no statistical variation was observed in improving clinical pregnancy rate (CPR), fertilization rate, high-quality embryo rate, luteinizing hormone (LH) value, anti-mullerian hormone (AMH) value, or reducing the dose of gonadotropin (Gn) values between the acupuncture plus COH therapy group and the COH therapy group.

Conclusion: Acupuncture combined with COH therapy is doubtful in improving the pregnancy outcome of POR patients. Secondly, acupuncture can also improve the sex hormone level of POR women, and improve ovarian function. Furthermore, more RCTs of acupuncture in POR are needed to be incorporated into future meta-analyses.

Systematic review registration: PROSPERO, identifier CRD42020169560.

Keywords: acupuncture; in vitro fertilization; ovarian function; poor ovarian response; systematic review.

Publication types

Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Acupuncture Therapy*
Female
Fertilization in Vitro
Gonadotropins
Humans
Ovarian Hyperstimulation Syndrome*
Pregnancy
Pregnancy Outcome

Substances

Gonadotropins

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant number 82174517 and grant number 81973966), 'Xinglin Scholars' Disciplinary Talent Research Promotion Plan Excellent Youth Project (YQRC2022001), and the Department of Science and Technology of Sichuan Province (grant number 2020JDJQ0051).