Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study

Takahiro Inoue; Hiroshi Kuji; Kanako Nagaoka; Takafumi Akanuma; Junko Fukuda; Hiroki Matsui; Hiroaki Tanabe; Mamiko Ohara; Tomo Suzuki

doi:10.1186/s12882-023-03142-0

Intraoperative hemodialysis during open-heart surgery in patients with severe chronic kidney disease: a retrospective cohort study

BMC Nephrol. 2023 Mar 30;24(1):78. doi: 10.1186/s12882-023-03142-0.

Authors

Takahiro Inoue¹, Hiroshi Kuji², Kanako Nagaoka¹, Takafumi Akanuma³, Junko Fukuda¹, Hiroki Matsui⁴, Hiroaki Tanabe⁵, Mamiko Ohara¹, Tomo Suzuki⁶

Affiliations

¹ Department of Nephrology, Kameda Medical Center, 929, Higashicho, Kamogawa, Chiba, 296-8602, Japan.
² Department of Urology, Kameda Medical Center, Kamogawa, Japan.
³ Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
⁴ Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
⁵ Department of Cardiovascular Surgery, Kameda Medical Center, Kamogawa, Japan.
⁶ Department of Nephrology, Kameda Medical Center, 929, Higashicho, Kamogawa, Chiba, 296-8602, Japan. suzuki.tomo@kameda.jp.

Abstract

Background: Acute kidney injury and chronic kidney disease (CKD) after cardiac surgery are associated with poor renal prognosis and increased mortality. The impact of intraoperative hemodialysis (IHD) on postoperative renal function remains unknown. We aimed to evaluate the utility of IHD during open-heart surgery in patients with severe non-dialysis-dependent chronic kidney disease (CKD-NDD) and its association with clinical outcomes.

Methods: This was a single-center retrospective cohort study that employed IHD during non-emergency open-heart surgery in patients with CKD stage G4 or G5. Patients who underwent emergent surgery, chronic dialysis, and/or kidney transplantation were excluded. We retrospectively compared the clinical characteristics and outcomes between patients from the IHD and non-IHD groups. The primary outcomes were 90-day mortality and postoperative initiation of renal replacement therapy (RRT).

Results: Twenty-eight patients were categorized into the IHD group and 33 into the non-IHD group. When comparing the IHD and non-IHD groups, men accounted for 60.7 vs. 50.3% of patients, the mean patient age was 74.5 (standard deviation [SD] 7.0) vs. 72.9 (SD 9.4) years (p = 0.744), and the proportion of patients with CKD G4 was 67.9 vs. 84.9% (p = 0.138). Regarding clinical outcomes, no significant differences were observed in the 90-day mortality (7.1 vs. 3.0%; p = 0.482) and 30-day RRT (17.9 vs. 30.3%; p = 0.373) rates between the groups. Among the patients with CKD G4, the IHD group had significantly lower 30-day RRT rates than the non-IHD group (0 vs. 25.0%; p = 0.032). RRT initiation was less likely for patients with CKD G4 (odds ratio 0.07, 95% confidence interval [CI] 0.01-0.37; p = 0.002); however, IHD did not significantly decrease the incidence of poor clinical outcomes (odds ratio 0.20, 95% CI 0.04-1.07; p = 0.061).

Conclusions: IHD during open-heart surgery in patients with CKD-NDD did not improve their clinical outcomes with regards to postoperative dialysis. However, for patients with CKD G4, IHD may be useful for postoperative cardiac management.

Keywords: Acute kidney injury; Cardiac surgery; Chronic kidney disease; Intraoperative hemodialysis.

MeSH terms

Acute Kidney Injury*
Cardiac Surgical Procedures*
Humans
Kidney
Male
Renal Dialysis
Renal Insufficiency, Chronic* / epidemiology
Renal Replacement Therapy
Retrospective Studies