[MIC2 (CD99) as a diagnostic marker for TdT-negative B lymphoblastic lymphoma]

Rinsho Ketsueki. 2023;64(2):130-132. doi: 10.11406/rinketsu.64.130.
[Article in Japanese]

Abstract

Lymphoblastic lymphoma (LBL) is a rare hematologic malignancy that originates from immature lymphocytes and usually expresses terminal deoxynucleotidyl transferase (TdT). Here, we report a case of TdT-negative B-LBL. A 71-year-old male patient presented to a hospital with shortness of breath. His chest computed tomography showed a mediastinal mass. Tumor cells did not express TdT but expressed MIC2, which led to LBL diagnosis. MIC2 is a useful marker for LBL diagnosis.

Keywords: CD99; Lymphoblastic lymphoma; MIC2; Terminal deoxynucleotidyl transferase.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • 12E7 Antigen
  • Aged
  • DNA Nucleotidylexotransferase / metabolism
  • Hematologic Neoplasms*
  • Humans
  • Lymphoma, Non-Hodgkin*
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis

Substances

  • 12E7 Antigen
  • CD99 protein, human
  • DNA Nucleotidylexotransferase