Targeted delivery of nutraceuticals derived from food for the treatment of obesity and its related complications

Zijian Dai; Yiyun Zhang; Yantong Meng; Siqi Li; Zhuoma Suonan; Yuge Sun; Junfu Ji; Qun Shen; Hao Zheng; Yong Xue

doi:10.1016/j.foodchem.2023.135980

Targeted delivery of nutraceuticals derived from food for the treatment of obesity and its related complications

Food Chem. 2023 Aug 30:418:135980. doi: 10.1016/j.foodchem.2023.135980. Epub 2023 Mar 22.

Authors

Zijian Dai¹, Yiyun Zhang¹, Yantong Meng¹, Siqi Li¹, Zhuoma Suonan¹, Yuge Sun¹, Junfu Ji², Qun Shen¹, Hao Zheng³, Yong Xue⁴

Affiliations

¹ College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, PR China; National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, PR China.
² College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, PR China; Xinghua Industrial Research Centre for Food Science and Human Health, China Agricultural University, Shinaian West Road, Xinghua, PR China.
³ College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, PR China.
⁴ College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, PR China; National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, PR China; Xinghua Industrial Research Centre for Food Science and Human Health, China Agricultural University, Shinaian West Road, Xinghua, PR China. Electronic address: xueyong@cau.edu.cn.

PMID: 36989644
DOI: 10.1016/j.foodchem.2023.135980

Abstract

Nutraceuticals which are abundant in foods have attracted much attention due to their bioactive activities of anti-obesity, anti-hyperlipidemia and anti-atherosclerosis. Unfortunately, the poor bioavailability severely undermines their envisioned benefits. Therefore, there is an urgent need to develop suitable delivery systems to promote the benefits of their biological activity. Targeted drug delivery system (TDDS) is a novel drug delivery system that can selectively concentrate drugs on targets in the body, improve the bioavailability of agents and reduce side effects. This emerging drug delivery system provides a new strategy for the treatment of obesity with nutraceuticals and would be a promising alternative to be widely used in the food field. This review summarizes the recent studies on the application in the targeted delivery of nutraceuticals for treating obesity and its related complications, especially the available receptors and their corresponding ligands for TDDS and the evaluation methods of the targeting ability.

Keywords: Atherosclerosis; Evaluation methods; Nanocarriers; Nonalcoholic fatty liver disease; Phytochemicals; Targeted delivery.

Publication types

Review

MeSH terms

Dietary Supplements*
Drug Delivery Systems / methods
Humans
Obesity* / drug therapy