Current Approach to Renal Transplantation Candidates and Potential Donors with Viral Hepatitis

Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 29;44(1):135-144. doi: 10.2478/prilozi-2023-0015. Print 2023 Mar 1.

Abstract

Renal transplantation is the most beneficial treatment in patients with chronic kidney disease (CKD), increasing life expectancy and improving quality of life. A better understanding of organ and tissue functions, the development of surgical techniques, and new and effective immunosuppressive and antimicrobial drugs increase the success of transplantation. However, the number of renal transplantations from living and cadaveric donors is not at the desired frequency. Among the leading causes of the restrictions for transplantation are both the recipients' and donors' chronic diseases. While hepatitis B and C infections are a significant problem affecting the number and success of renal transplantations, the innovation of hepatitis C virus treatments has improved outcomes. Thus, the recipient and donor hepatitis B and C virus infections are no longer considered as relative contraindications for renal transplantation. This review discusses the management of patients and donors with hepatitis B and hepatitis C in renal transplantation.

Keywords: Direct-acting antiviral agents; Hepatitis B Virus; Hepatitis C Virus; Renal Transplantation.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • Hepacivirus
  • Hepatitis B* / diagnosis
  • Hepatitis B* / drug therapy
  • Hepatitis B* / etiology
  • Hepatitis C* / drug therapy
  • Hepatitis C* / etiology
  • Hepatitis, Viral, Human* / drug therapy
  • Hepatitis, Viral, Human* / etiology
  • Humans
  • Kidney Transplantation* / adverse effects
  • Quality of Life
  • Tissue Donors

Substances

  • Antiviral Agents