Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil

Manyu Zhang; Jinwei Ren; Yuanming Luo; Weidong Xie; Erwei Li

doi:10.3390/molecules28062579

Polyene Carboxylic Acids from a Streptomyces sp. Isolated from Tibet Soil

Molecules. 2023 Mar 12;28(6):2579. doi: 10.3390/molecules28062579.

Authors

Manyu Zhang^{1

2}, Jinwei Ren³, Yuanming Luo², Weidong Xie¹, Erwei Li²

Affiliations

¹ Marine College, Shandong University, Weihai 264209, China.
² Institutional Center for Shared Technologies and Facilities, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
³ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

Six new polyene carboxylic acids named serpentemycins E-J (1-6), together with three known analogs (7-9), were isolated from the fermentation medium of Streptomyces sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated mainly on the basis of HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds 1-9 against NO production in LPS-activated RAW264.7 cells were evaluated. Compound 9 has an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 µM.

Keywords: NO production; bioactivity; polyene carboxylic acid; secondary metabolites.

MeSH terms

Carboxylic Acids* / pharmacology
Magnetic Resonance Spectroscopy
Polyenes / chemistry
Streptomyces* / chemistry
Tibet

Substances

Carboxylic Acids
Polyenes

Grants and funding

This research received no external funding.