An Investigation into Compound Likelihood Ratios for Forensic DNA Mixtures

Genes (Basel). 2023 Mar 14;14(3):714. doi: 10.3390/genes14030714.

Abstract

Simple propositions are defined as those with one POI and the remaining contributors unknown under Hp and all unknown contributors under Ha. Conditional propositions are defined as those with one POI, one or more assumed contributors, and the remaining contributors (if any) unknown under Hp, and the assumed contributor(s) and N unknown contributors under Ha. In this study, compound propositions are those with multiple POI and the remaining contributors unknown under Hp and all unknown contributors under Ha. We study the performance of these three proposition sets on thirty-two samples (two laboratories × four NOCs × four mixtures) consisting of four mixtures, each with N = 2, N = 3, N = 4, and N = 5 contributors using the probabilistic genotyping software, STRmix™. In this study, it was found that conditional propositions have a much higher ability to differentiate true from false donors than simple propositions. Compound propositions can misstate the weight of evidence given the propositions strongly in either direction.

Keywords: forensic DNA analysis; likelihood ratios; mixtures; propositions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / genetics
  • DNA Fingerprinting*
  • Likelihood Functions
  • Microsatellite Repeats*
  • Software

Substances

  • DNA

Grants and funding

This work was supported in part by grant NIJ 2020-DQ-BX-0022 from the US National Institute of Justice.