Breaking Up Isn't Hard to Do: Isolating Cell-free DNA Fragments in Osteosarcoma

Clin Cancer Res. 2023 Jun 1;29(11):2017-2019. doi: 10.1158/1078-0432.CCR-23-0390.

Abstract

The novel use of blood-based biospecimens from a retrospective cohort of 50 patients with osteosarcoma was recently studied. The potential clinical utility of sorting cell-free DNA by fragment size was defined, with shorter tumor-specific DNA enrichment providing prognostic value and allowing for streamlined molecular profiling of circulating tumor material. See related article by Udomruk et al., p. 2085.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bone Neoplasms* / diagnosis
  • Bone Neoplasms* / genetics
  • Cell-Free Nucleic Acids* / genetics
  • DNA, Neoplasm / genetics
  • Humans
  • Osteosarcoma* / diagnosis
  • Osteosarcoma* / genetics
  • Osteosarcoma* / therapy
  • Prognosis
  • Retrospective Studies

Substances

  • Cell-Free Nucleic Acids
  • DNA, Neoplasm