Regulation of SIRT1 in Ovarian Function: PCOS Treatment

Xinrong Li; Yuxu He; Shuang Wu; Peiwen Zhang; Mailin Gan; Lei Chen; Ye Zhao; Lili Niu; Shunhua Zhang; Yanzhi Jiang; Zongyi Guo; Jinyong Wang; Linyuan Shen; Li Zhu

doi:10.3390/cimb45030133

Regulation of SIRT1 in Ovarian Function: PCOS Treatment

Curr Issues Mol Biol. 2023 Mar 2;45(3):2073-2089. doi: 10.3390/cimb45030133.

Authors

Xinrong Li^{1

2}, Yuxu He^{1

2}, Shuang Wu^{1

2}, Peiwen Zhang^{1

2}, Mailin Gan^{1

2}, Lei Chen^{1

2}, Ye Zhao^{1

2}, Lili Niu^{1

2}, Shunhua Zhang^{1

2}, Yanzhi Jiang³, Zongyi Guo⁴, Jinyong Wang⁴, Linyuan Shen^{1

2}, Li Zhu^{1

2}

Affiliations

¹ Department of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
² Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
³ College of Life Science, Sichuan Agricultural University, Chengdu 611130, China.
⁴ Chongqing Academy of Animal Science, Rongchang, Chongqing 402460, China.

Abstract

The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. In recent years, it has been found that caloric restriction increases ovarian reserves, suggesting that sirtuins may play a regulatory role in reproductive capacity, and interest in the sirtuin family has continued to increase. The purpose of this paper is to summarize the existing studies and analyze the role and mechanism of SIRT1, a member of the sirtuin family, in regulating ovarian function. Research and review on the positive regulation of SIRT1 in ovarian function and its therapeutic effect on PCOS syndrome.

Keywords: SIRT1; follicle development; granulosa cells; ovary; research progress.

Publication types

Review

Grants and funding

This research was funded by National Key Research and Development Program of China, grant number: No.2021YFD1200801; Sichuan Science and Technology Program, grant number: No.2020YFN0147, No.2021ZDZX0008; The Program for Pig Industry Technology System Innovation Team of Sichuan Province, No. scsztd-2021-08-09; China Agriculture Research System of MOF and MARA.