The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis

J Cell Mol Med. 2023 May;27(9):1261-1276. doi: 10.1111/jcmm.17731. Epub 2023 Mar 28.

Abstract

A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we found that Circ_35953 was induced by LPS via activation of NF-κB signal in BUMPT cells. Functionally, Circ_35953 mediated the LPS induced the apoptosis in BUMPT cells. Moreover, we demonstrated that Circ_35953 sponged miR-7219-5p to upregulate the expression of HOOK3 and IGFBP7. Finally, we verified that knock down of Circ_35953 alleviated the progression of CLP-induced AKI via targeting the miR-7219-5p/HOOK3 and IGFBP7 signal. Collectively, the data suggested that Circ_35953 /miR-7219-5p/HOOK3 and IGFBP7 axis mediated the septic AKI, which also revealed a potential mechanism of septic AKI.

Keywords: CircRNA; apoptosis; septic AKI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury* / genetics
  • Apoptosis / genetics
  • Humans
  • Lipopolysaccharides
  • MicroRNAs* / genetics
  • Microtubule-Associated Proteins
  • NF-kappa B / genetics
  • RNA, Circular / genetics

Substances

  • NF-kappa B
  • Lipopolysaccharides
  • RNA, Circular
  • MicroRNAs
  • hook3 protein, human
  • Microtubule-Associated Proteins