Adaptive aggregation for longitudinal quantile regression based on censored history process

Stat Methods Med Res. 2023 Jun;32(6):1169-1192. doi: 10.1177/09622802231164730. Epub 2023 Mar 28.

Abstract

Most of the studies for longitudinal quantile regression are based on the correct specification. Nevertheless, one specific model can hardly perform precisely under different conditions and assessing which conditions are (approximately) satisfied to determine the optimal one is rather difficult. In the case of the mixed effect model, the misspecification of the fixed effect part will cause a lack of predicting accuracy of random effects, and affect the efficiency of the cumulative function estimator. On the other hand, limited research has focused on incorporating multiple candidate procedures in longitudinal data analysis, which is of current emergency. This paper proposes an exponential aggregation weighting algorithm for longitudinal quantile regression. Based on the secondary smoothing loss function, we establish oracle inequalities for aggregated estimator. The proposed method is applied to evaluate the cumulative τth quantile function for additive mixed effect model with right-censored history process, and an aggregation-based best linear prediction for random effects is constructed as well. We show that the asymptotic properties are conveniently imposed owing to the smoothing scheme. Simulation studies are carried out to exhibit the rationality, and our method is illustrated to analyze the data set from a multicenter automatic defibrillator implantation trial.

Keywords: Aggregation; longitudinal quantile regression; random effect; right censoring; smoothing loss function.

Publication types

  • Multicenter Study

MeSH terms

  • Algorithms*
  • Computer Simulation