Insight into the effect of biomaterials on osteogenic differentiation of mesenchymal stem cells: A review from a mitochondrial perspective

Ziyi Feng; Meiqi Jin; Junzhi Liang; Junning Kang; Huazhe Yang; Shu Guo; Xiaoting Sun

doi:10.1016/j.actbio.2023.03.032

Insight into the effect of biomaterials on osteogenic differentiation of mesenchymal stem cells: A review from a mitochondrial perspective

Acta Biomater. 2023 Jul 1:164:1-14. doi: 10.1016/j.actbio.2023.03.032. Epub 2023 Mar 25.

Authors

Ziyi Feng¹, Meiqi Jin², Junzhi Liang³, Junning Kang⁴, Huazhe Yang⁵, Shu Guo⁶, Xiaoting Sun⁷

Affiliations

¹ Department of Plastic Surgery, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning 110002, China.
² School of Intelligent Medicine, China Medical University, No.77, Puhe Road, Shenyang, Liaoning 110122, China.
³ Center of Reproductive Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning 110004, China.
⁴ Department of Neurosurgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping, Shenyang, Liaoning 110004, China.
⁵ School of Intelligent Medicine, China Medical University, No.77, Puhe Road, Shenyang, Liaoning 110122, China. Electronic address: hzyang@cmu.edu.cn.
⁶ Department of Plastic Surgery, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning 110002, China. Electronic address: sguo@cmu.edu.cn.
⁷ School of Forensic Medicine, China Medical University, No.77, Puhe Road, Shenyang, Liaoning 110122, China. Electronic address: xtsun@cmu.edu.cn.

PMID: 36972808
DOI: 10.1016/j.actbio.2023.03.032

Abstract

Bone damage may be triggered by a variety of factors, and the damaged area often requires a bone graft. Bone tissue engineering can serve as an alternative strategy for repairing large bone defects. Mesenchymal stem cells (MSCs), the progenitor cells of connective tissue, have become an important tool for tissue engineering due to their ability to differentiate into a variety of cell types. The precise regulation of the growth and differentiation of the stem cells used for bone regeneration significantly affects the efficiency of this type of tissue engineering. During the process of osteogenic induction, the dynamics and function of localized mitochondria are altered. These changes may also alter the microenvironment of the therapeutic stem cells and result in mitochondria transfer. Mitochondrial regulation not only affects the induction/rate of differentiation, but also influences its direction, determining the final identity of the differentiated cell. To date, bone tissue engineering research has mainly focused on the influence of biomaterials on phenotype and nuclear genotype, with few studies investigating the role of mitochondria. In this review, we provide a comprehensive summary of researches into the role of mitochondria in MSCs differentiation and critical analysis regarding smart biomaterials that are able to "programme" mitochondria modulation was proposed. STATEMENT OF SIGNIFICANCE: This review proposed the precise regulation of the growth and differentiation of the stem cells used to seed bone regeneration. • This review addressed the dynamics and function of localized mitochondria during the process of osteogenic induction and the effect of mitochondria on the microenvironment of stem cells. • This review summarized biomaterials which affect the induction/rate of differentiation, but also influences its direction, determining the final identity of the differentiated cell through the regulation of mitochondria.

Keywords: Biomaterials; Bone tissue engineering; Mesenchymal stem cells; Mitochondria; Osteogenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / pharmacology
Cell Differentiation
Mesenchymal Stem Cells*
Mitochondria
Osteogenesis*

Substances

Biocompatible Materials