How much do molecular shapes matter?

Mohan Bhadbhade

doi:10.1107/S2052520623002627

How much do molecular shapes matter?

Acta Crystallogr B Struct Sci Cryst Eng Mater. 2023 Apr 1;79(Pt 2):101-103. doi: 10.1107/S2052520623002627. Epub 2023 Mar 25.

Author

Mohan Bhadbhade¹

Affiliation

¹ Mark Wainwright Analytical Centre, The University of New South Wales (UNSW), Sydney, NSW 2052, Australia.

PMID: 36972175
DOI: 10.1107/S2052520623002627

Abstract

Nifedipine (NIF) molecules (L-type calcium channel antagonists) pack in solvated structures showing strikingly similar patterns, see Jones et al. [Acta Cryst. (2023), B79, 164-175]. How much do molecular shapes, such as the NIF molecule which resembles the letter T, matter in their associations in crystals?

Keywords: nifedipine; pharmaceutical; polymorphism; solvate.