Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

Nicole M Rossi; Jieqiong Dai; Yi Xie; Darawalee Wangsa; Kerstin Heselmeyer-Haddad; Hong Lou; Joseph F Boland; Meredith Yeager; Roberto Orozco; Enrique Alvirez Freites; Lisa Mirabello; Eduardo Gharzouzi; Michael Dean

doi:10.1158/0008-5472.CAN-22-3030

Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis

Cancer Res. 2023 Jun 2;83(11):1768-1781. doi: 10.1158/0008-5472.CAN-22-3030.

Authors

Affiliations

¹ Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
² Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Frederick, Maryland.
³ Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
⁴ Hospital General San Juan de Dios, Guatemala.
⁵ Hospital Central Universitario "Dr. Antonio M Pineda," Barquisimeto, Lara State, Venezuela, and Universidad Andino de Cusco, Cusco, Perú.
⁶ Integra Cancer Center, Guatemala City, Guatemala.

^# Contributed equally.

Abstract

Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Cell Transformation, Neoplastic
Cervix Uteri
Female
Human Papillomavirus Viruses
Humans
Papillomaviridae / genetics
Papillomavirus Infections* / complications
Plasmids
Uterine Cervical Neoplasms* / genetics

Abstract

Publication types

MeSH terms

Grants and funding