Research progress of endogenous hematoma absorption after intracerebral hemorrhage

Peijie Fu; Manqing Zhang; Moxin Wu; Weixin Zhou; Xiaoping Yin; Zhiying Chen; Chuanjun Dan

doi:10.3389/fneur.2023.1115726

Research progress of endogenous hematoma absorption after intracerebral hemorrhage

Front Neurol. 2023 Mar 10:14:1115726. doi: 10.3389/fneur.2023.1115726. eCollection 2023.

Authors

Peijie Fu^{1

2}, Manqing Zhang³, Moxin Wu^{1

2}, Weixin Zhou^{1

2}, Xiaoping Yin^{1

2}, Zhiying Chen^{1

2}, Chuanjun Dan⁴

Affiliations

¹ Department of Neurology, Clinical Medical School of Jiujiang University, Jiujiang, Jiangxi, China.
² Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi, China.
³ Medical College of Jiujiang University, Jiujiang, Jiangxi, China.
⁴ Emergency Department, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China.

Abstract

Non-traumatic intraparenchymal brain hemorrhage is referred to as intracerebral hemorrhage (ICH). Although ICH is associated with a high rate of disability and case fatality, active intervention can significantly lower the rate of severe disability. Studies have shown that the speed of hematoma clearance after ICH determines the patient's prognosis. Following ICH, depending on the hematoma volume and mass effect, either surgical- or medication-only conservative treatment is chosen. The goal of promoting endogenous hematoma absorption is more relevant because surgery is only appropriate for a small percentage of patients, and open surgery can cause additional trauma to patients. The primary method of removing hematoma after ICH in the future will involve understanding how to produce and manage macrophage/microglial endogenous phagocytic hematomas. Therefore, it is necessary to elucidate the regulatory mechanisms and key targets for clinical purposes.

Keywords: haematoma absorption; intracerebral hemorrhage; microglia; phagocytosis; scavenger receptor.

Publication types

Review

Grants and funding

This study was partially supported by the National Natural Science Foundation of China (81960221 and 82260249 to XY), the National Science & Technology Fundamental Resource Investigation Program of China (2018FY100903 to XY), the Jiangxi Provincial Health Commission Science and Technology Plan Project (202311506 to ZC), the Jiangxi Provincial Administration of Traditional Chinese Medicine Science and Technology Plan Project (2022A322 to ZC), and the Science and Technology Project Founded by the Education Department of Jiangxi Province (GJJ21181 to CD).