Advances in biotechnology and clinical therapy in the field of peripheral nerve regeneration based on magnetism

Zheyuan Fan; Xinggui Wen; Xiangdong Ding; Qianqian Wang; Shoushuai Wang; Wei Yu

doi:10.3389/fneur.2023.1079757

Advances in biotechnology and clinical therapy in the field of peripheral nerve regeneration based on magnetism

Front Neurol. 2023 Mar 10:14:1079757. doi: 10.3389/fneur.2023.1079757. eCollection 2023.

Authors

Zheyuan Fan¹, Xinggui Wen¹, Xiangdong Ding¹, Qianqian Wang¹, Shoushuai Wang¹, Wei Yu¹

Affiliation

¹ Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Abstract

Peripheral nerve injury (PNI) is one of the most common neurological diseases. Recent studies on nerve cells have provided new ideas for the regeneration of peripheral nerves and treatment of physical trauma or degenerative disease-induced loss of sensory and motor neuron functions. Accumulating evidence suggested that magnetic fields might have a significant impact on the growth of nerve cells. Studies have investigated different magnetic field properties (static or pulsed magnetic field) and intensities, various magnetic nanoparticle-encapsulating cytokines based on superparamagnetism, magnetically functionalized nanofibers, and their relevant mechanisms and clinical applications. This review provides an overview of these aspects as well as their future developmental prospects in related fields.

Keywords: magnetic field; magnetic nanoparticles; magnetical nanofibers; peripheral nerve regeneration; repetitive peripheral magnetic stimulation.

Publication types

Review

Grants and funding

This study was supported by the Research Project of the Education Department of Jilin Province (No. JJKH20211187KJ) and the Industrial Technology Research and Development of the Development and Reform Commission of Jilin Province (No. 2021C042-4).