Peroxidase-like MoS2/Ag nanosheets with synergistically enhanced NIR-responsive antibacterial activities

Huiying Chen; Xinshuo Zhao; Bingbing Cui; Haohao Cui; Mengyang Zhao; Jun Shi; Jingguo Li; Zhan Zhou

doi:10.3389/fchem.2023.1148354

Peroxidase-like MoS₂/Ag nanosheets with synergistically enhanced NIR-responsive antibacterial activities

Front Chem. 2023 Mar 9:11:1148354. doi: 10.3389/fchem.2023.1148354. eCollection 2023.

Authors

Huiying Chen^{1

2}, Xinshuo Zhao³, Bingbing Cui^{1

2}, Haohao Cui^{1

2}, Mengyang Zhao¹, Jun Shi², Jingguo Li¹, Zhan Zhou^{1

3}

Affiliations

¹ Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
² School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, China.
³ Henan Key Laboratory of Function-Oriented Porous Materials, College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, China.

Abstract

Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS₂) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of H₂O₂. The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS₂ nanosheets, the MoS₂/Ag nanosheets (denoted as MoS₂/Ag NSs) exhibited better antibacterial performance against Staphylococcus aureus by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS₂/Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS₂/Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.

Keywords: peroxidase-like activity; photo-responsive; silver nanoparticles; synergistic antibacterial; two-dimensional.

Grants and funding

This work is supported by the National Natural Science Foundation of China (52173143 and 52102348), the China Postdoctoral Science Foundation (No. 2021M701113) and the Key Scientific Research Project of Higher Education of Henan Province (21A150003).