The abnormal umbilical venous-arterial index in the second half of pregnancy is associated with fetal outcome: A retrospective cross-sectional study

Ling Wang; Dan Zhou; Baiguo Long; Jiqing Wang; Lingling Li; Yang Peng; Qichang Zhou; Shi Zeng

doi:10.3389/fped.2023.1036359

The abnormal umbilical venous-arterial index in the second half of pregnancy is associated with fetal outcome: A retrospective cross-sectional study

Front Pediatr. 2023 Mar 10:11:1036359. doi: 10.3389/fped.2023.1036359. eCollection 2023.

Authors

Ling Wang¹, Dan Zhou², Baiguo Long¹, Jiqing Wang¹, Lingling Li³, Yang Peng¹, Qichang Zhou², Shi Zeng²

Affiliations

¹ Department of Ultrasound, Women and Children Healthcare Hospital of Zhu Zhou, Zhuzhou, China.
² Department of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South University, Changsha, China.
³ Department of Ultrasound, Women and Children Healthcare Hospital of Changsha, Changsha, China.

Abstract

Objective: This study aims to observe the changes of the umbilical venous-arterial index (VAI) and investigate its predictive power for fetal outcome during the second half of pregnancy.

Methods: Fetuses with gestational age (GA) at 24-39 weeks were collected. According to the outcome score, neonates with outcome scores of 0, 1, or 2 were assigned to the control group, whereas those with scores of 3-12 were assigned to the compromised group. VAI was calculated as the ratio of normalized umbilical vein blood flow volume and umbilical artery pulsatility index. Regression analysis was performed to obtain the best-fitting curves between VAI and GA in the controls. Doppler parameters and perinatal outcomes were compared in both groups. Receiver operating characteristic analysis was used to assess the diagnostic performance of the VAI.

Results: A total of 833 (95%) fetuses had Doppler parameters and pregnancy outcomes documented. Compared with the controls, the VAI was significantly lower in the compromised group (83.2 vs. 184.8 ml/min/kg, p < 0.001). The sensitivity and specificity of VAI to predict compromised neonates were 95.15% (95% Cl, 89.14 to 97.91%) and 99.04% (95% CI: 98.03 to 99.53%), respectively at a cutoff value of 120 ml/min/kg.

Conclusions: VAI presents better diagnostic performance than umbilical vein blood flow volume and umbilical artery pulsatility index. A cutoff value of 120 ml/min/kg might be used as the warning value for predicting the fetal outcome.

Keywords: fetal outcome; normalized umbilical vein blood flow volume; umbilical artery pulsatility index; umbilical vein blood flow volume; venous-arterial index.

Grants and funding

This study was supported by the Natural Science Foundation of Hunan Province (Grant number: 2017JJ4060) and Health Commission of Hunan Province (Grant number: B2017159).