Experimental mouse models for translational human cancer research

Front Immunol. 2023 Mar 10:14:1095388. doi: 10.3389/fimmu.2023.1095388. eCollection 2023.

Abstract

The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required. The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research. In this paper, we have reviewed recent research progress in relation to mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, to help guide the future study of malignant mechanisms and tumor prevention.

Keywords: PDX; animal model; immune microenvironment; immunodeficiency; induced; spontaneity; transgene; tumor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Disease Models, Animal
  • Hematologic Neoplasms*
  • Humans
  • Immunotherapy, Adoptive / methods
  • Mice
  • Neoplasms* / genetics
  • Neoplasms* / therapy
  • Rats

Grants and funding

This study was funded by the National Natural Science Foundation of China (82002421), the Young Talent Program of Tangdu Hospital, Health Research Fund of Shaanxi Province (2021B004), and the Discipline Innovation Development Plan Project of Tangdu Hospital (2021LCYJ005).