Application of low dose aspirin in pre-eclampsia

Yu Ren; Yong Zhao; Xiangdong Yang; Chaojun Shen; Hua Luo

doi:10.3389/fmed.2023.1111371

Application of low dose aspirin in pre-eclampsia

Front Med (Lausanne). 2023 Mar 8:10:1111371. doi: 10.3389/fmed.2023.1111371. eCollection 2023.

Authors

Yu Ren¹, Yong Zhao², Xiangdong Yang³, Chaojun Shen⁴, Hua Luo⁴

Affiliations

¹ Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.
² Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai, China.
³ Department of Orthopedics, Ningbo First Hospital, The Affiliated Hospital of Zhejiang University, Ningbo, China.
⁴ Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.

Abstract

Aspirin is widely used in the primary and secondary prevention of cardiovascular and cerebrovascular diseases. Low-dose aspirin is also widely used to prevent pre-eclampsia and fetal growth retardation in utero. However, the use of aspirin during pregnancy is controversial. Since 1985, when aspirin was reported to be effective in obstetrics, numerous studies have attempted to determine the effect of low-dose aspirin on the morbidity of pre-eclampsia but have remained inconclusive. Guidelines for aspirin in preventing pre-eclampsia are different in different countries and regions. This article summarizes the research progress, mechanism, and application prospect of aspirin in preventing pre-eclampsia, providing a theoretical basis for the rational use of aspirin in pregnancy.

Keywords: aspirin; cerebrovascular disease; guideline; low-dose; pre-eclampsia.

Publication types

Review