Advances in self-assembled Au-DNA nanomachines

Qianying Zhang; Shengshi Xu; Jingyi Zheng; Jian-Rong Zhang; Jun-Jie Zhu

doi:10.1016/j.isci.2023.106327

Advances in self-assembled Au-DNA nanomachines

iScience. 2023 Mar 3;26(4):106327. doi: 10.1016/j.isci.2023.106327. eCollection 2023 Apr 21.

Authors

Qianying Zhang¹, Shengshi Xu¹, Jingyi Zheng¹, Jian-Rong Zhang¹, Jun-Jie Zhu^{1

2}

Affiliations

¹ State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
² Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China.

Abstract

Au-DNA self-assembled nanomachines can perform intelligent tasks such as sensing biomarkers and delivery of drug molecules through rational customization and programming. By virtue of their efficient signal amplification and flexible scalability, Au-DNA nanomachines have developed into one of the most promising nanodevices. In this review, we summarize the latest progress in Au-DNA self-assembled nanomachines for biosensing applications. First, the functional modules for building Au-DNA nanomachines are introduced. Subsequently, we summarize the biosensing applications of Au-DNA nanomachines with electrochemical or fluorescent signals as the output, respectively. Finally, we discuss the challenges and potential opportunities for Au-DNA nanomachines in biomedical applications.

Keywords: Materials chemistry; Materials science; Materials synthesis.

Publication types

Review