Chemokines in patients with Alzheimer's disease: A meta-analysis

Hecheng Wang; Yu Zong; Lei Zhu; Weiyi Wang; Yanshuo Han

doi:10.3389/fnagi.2023.1047810

Chemokines in patients with Alzheimer's disease: A meta-analysis

Front Aging Neurosci. 2023 Mar 9:15:1047810. doi: 10.3389/fnagi.2023.1047810. eCollection 2023.

Authors

Hecheng Wang¹, Yu Zong¹, Lei Zhu¹, Weiyi Wang², Yanshuo Han¹

Affiliations

¹ School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China.
² Department of Cardiovascular Diseases, Civil Aviation General Hospital, Peking University, Beijing, China.

Abstract

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly people. Many researches have reported that neuroinflammation is related to AD. Chemokines are a class of small cytokines that play important roles in cell migration and cell communication, which involved in neuroinflammation. Up to now there is no meta-analysis to explore the difference of chemokines between AD patients and healthy elderly individuals.

Method: We searched PubMed, Web of science, Cochrane library, EMBASE and Scopus databases from inception to January 2022. Data were extracted by two independent reviewers, and the Review Manager 5.3 was used for the meta-analysis.

Result: Thirty-two articles were included and analyzed. The total number of participants in the included study was 3,331. We found that the levels of CCL5 (SMD = 2.56, 95% CI: 1.91-3.21), CCL15 (SMD = 3.30, 95% CI: 1.48-5.13) and IP-10 (SMD = 3.88, 95% CI: 1.84-5.91) in the plasma of AD patients were higher than healthy people. MCP-1 protein (SMD = 0.67, 95% CI: 0.29-1.05) in the AD patients' CSF was higher than healthy controls.

Conclusion: These results suggested that chemokines may play an important role in AD. These findings could provide evidences for the diagnosis and treatment of AD.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278736, identifier: CRD42021278736.

Keywords: Alzheimer's disease; CSF; chemokines; meta-analysis; plasma.

Publication types

Systematic Review

Grants and funding

The following grants supported this research: the Fundamental Research Funds for Civil Aviation General Hospital (No. 202211) and the Fundamental Research Funds for the Central Universities (Nos. DUT21RC(4)003 and DUT22YG107).