Modularized synthetic biology enabled intelligent biosensors

Chao Zhang; Hao Liu; Xiujun Li; Feng Xu; Zedong Li

doi:10.1016/j.tibtech.2023.03.005

Modularized synthetic biology enabled intelligent biosensors

Trends Biotechnol. 2023 Aug;41(8):1055-1065. doi: 10.1016/j.tibtech.2023.03.005. Epub 2023 Mar 25.

Authors

Chao Zhang¹, Hao Liu¹, Xiujun Li², Feng Xu³, Zedong Li⁴

Affiliations

¹ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China.
² Department of Chemistry and Biochemistry, University of Texas at El Paso, 500 West University Ave, El Paso, TX 79968, USA.
³ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China. Electronic address: fengxu@mail.xjtu.edu.cn.
⁴ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China; TFX Group-Xi'an Jiaotong University Institute of Life Health, Xi'an 710049, P.R. China. Electronic address: zedong@mail.xjtu.edu.cn.

PMID: 36967259
DOI: 10.1016/j.tibtech.2023.03.005

Abstract

Biosensors that sense the concentration of a specified target and produce a specific signal output have become important technology for biological analysis. Recently, intelligent biosensors have received great interest due to their adaptability to meet sophisticated demands. Advances in developing standard modules and carriers in synthetic biology have shed light on intelligent biosensors that can implement advanced analytical processing to better accommodate practical applications. This review focuses on intelligent synthetic biology-enabled biosensors (SBBs). First, we illustrate recent progress in intelligent SBBs with the capability of computation, memory storage, and self-calibration. Then, we discuss emerging applications of SBBs in point-of-care testing (POCT) and wearable monitoring. Finally, future perspectives on intelligent SBBs are proposed.

Keywords: intelligent biosensor; point-of-care testing; synthetic biology; wearable monitoring.

Publication types

Review

MeSH terms

Biosensing Techniques*
Synthetic Biology*
Technology