The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring

Hisataka Kobayashi; Peter L Choyke; Mikako Ogawa

doi:10.1016/j.cbpa.2023.102289

The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring

Curr Opin Chem Biol. 2023 Jun:74:102289. doi: 10.1016/j.cbpa.2023.102289. Epub 2023 Mar 24.

Authors

Hisataka Kobayashi¹, Peter L Choyke², Mikako Ogawa³

Affiliations

¹ Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-1088, United States. Electronic address: kobayash@mail.nih.gov.
² Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-1088, United States.
³ Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812, Japan.

PMID: 36966701
PMCID: PMC10225316 (available on 2024-06-01)
DOI: 10.1016/j.cbpa.2023.102289

Abstract

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer therapy based on the photo-induced ligand release reaction of a silicon-phthalocyanine derivative, IRDye700DX (IR700), that causes rapid cell death. Following exposure to an antibody-IR700-conjugate, cells exposed to NIR light within minutes undergo rapid swelling, blebbing, and finally, bursting. The photo-induced ligand release reaction also induces immediate loss of IR700 fluorescence due to dimerization or aggregation of the antibody-IR700 conjugate allowing for real time monitoring of NIR-PIT therapy.

Published by Elsevier Ltd.

Publication types

Review
Research Support, N.I.H., Intramural

MeSH terms

Cell Line, Tumor
Immunotherapy
Ligands
Phototherapy*
Silicon*
Xenograft Model Antitumor Assays

Substances

Silicon
phthalocyanine
Ligands

Grants and funding

ZIA BC011513/ImNIH/Intramural NIH HHS/United States